Compound Detail
CHEMBL1907790
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Basic Information
| ChEMBL ID | CHEMBL1907790 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZANRTNJFDQLKN-SECBINFHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
266.2
MW (Da)
-0.31
ALogP
4
HBA
4
HBD
115.7
PSA (Ų)
0.32
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neprilysin CHEMBL3768 | IC50 | 5.47 | 5.47 | 3350.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neprilysin | IC50 | = | 3350.0 | nM | 5.47 | Inhibition of [3H]Ala2-Leu-enkephalin binding to Neutral endopeptidase (NEP) | 2900898 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2900898 | 10.1021/jm00117a025 | Unchecked | 2 |
| 2900898 | 10.1021/jm00117a025 | Neprilysin | 1 |
Data from ChEMBL 36 via Core Engine