Assay Detail
Binding
CHEMBL646467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.47 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17107 | — | — | 1 | 9.00 |
| CHEMBL16779 | — | — | 1 | 8.70 |
| CHEMBL16457 | — | — | 1 | 8.60 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 8.30 |
| CHEMBL16046 | — | — | 1 | 8.15 |
| CHEMBL16622 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17107 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL16779 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL16457 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL16046 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL16622 | — | IC50 | = | 8.5 | nM | 8.07 |