Assay Detail
Binding
CHEMBL646481
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Binding affinity at adenosine A2 receptor from rat striatal membranes by [3H]NECA displacement.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.00 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181971 | — | — | 1 | 8.31 |
| CHEMBL604818 | — | — | 1 | 8.25 |
| CHEMBL603791 | — | — | 1 | 8.06 |
| CHEMBL604819 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181971 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL604818 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL603791 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL604819 | — | Ki | = | 43.0 | nM | 7.37 |