Assay Detail
Binding
CHEMBL646484
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Binding affinity towards adenosine A2 receptor on rat striatal membrane using [3H]NECA as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.70 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181971 | — | — | 1 | 8.31 |
| CHEMBL132960 | — | — | 1 | 8.04 |
| CHEMBL464859 | NECA | — | 1 | 7.92 |
| CHEMBL193692 | — | — | 1 | 7.60 |
| CHEMBL604967 | — | — | 1 | 7.32 |
| CHEMBL285819 | — | — | 1 | 7.20 |
| CHEMBL139000 | (R)-PIA | — | 1 | 6.92 |
| CHEMBL1256672 | — | — | 1 | 6.92 |
| CHEMBL1257013 | — | — | 1 | 6.80 |
| CHEMBL604617 | — | — | 1 | 6.64 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.55 |
| CHEMBL609501 | — | — | 1 | 6.41 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.34 |
| CHEMBL609790 | — | — | 1 | 5.37 |
| CHEMBL606227 | — | — | 1 | 4.54 |
| CHEMBL604961 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181971 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL132960 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL464859 | NECA | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL193692 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL604967 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL285819 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL139000 | (R)-PIA | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1256672 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1257013 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL604617 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL388757 | N6-BENZYLADENOSINE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL609501 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL609790 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL606227 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL604961 | — | Ki | = | 42000.0 | nM | 4.38 |