Assay Detail
Binding
CHEMBL646537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of intestinal Acyl coenzyme A:cholesterol acyltransferase in cholesterol-fed rabbits.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Acyl-CoA:cholesterol acyltransferase (CHEMBL6141) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Substituted N,N-diphenyl ureas as potent inhibitors of acyl-CoA:Cholesterol acyltransferase (ACAT)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.35 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88148 | — | — | 1 | 8.05 |
| CHEMBL90110 | — | — | 1 | 8.05 |
| CHEMBL87050 | — | — | 1 | 7.96 |
| CHEMBL89694 | — | — | 1 | 7.96 |
| CHEMBL313793 | — | — | 1 | 7.89 |
| CHEMBL87183 | — | — | 1 | 7.82 |
| CHEMBL86421 | — | — | 1 | 7.72 |
| CHEMBL89642 | — | — | 1 | 7.58 |
| CHEMBL89544 | — | — | 1 | 7.54 |
| CHEMBL86802 | — | — | 1 | 7.50 |
| CHEMBL86722 | — | — | 1 | 7.42 |
| CHEMBL89843 | — | — | 1 | 7.18 |
| CHEMBL264863 | — | — | 1 | 7.00 |
| CHEMBL277986 | CL-277082 | — | 1 | 6.92 |
| CHEMBL89574 | — | — | 1 | 6.78 |
| CHEMBL86681 | — | — | 1 | 6.60 |
| CHEMBL177678 | — | — | 1 | 6.30 |
| CHEMBL89873 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88148 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL90110 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL87050 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL89694 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL313793 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL87183 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL86421 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL89642 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL89544 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL86802 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL86722 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL89843 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL264863 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL277986 | CL-277082 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL89574 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL86681 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL177678 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL89873 | — | IC50 | = | 910.0 | nM | 6.04 |