Assay Detail
Binding
CHEMBL646574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards alpha-1 adrenergic receptor using radioligand [3H]prazosin
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.58 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204234 | — | — | 1 | 9.40 |
| CHEMBL1204250 | — | — | 1 | 8.28 |
| CHEMBL1204245 | — | — | 1 | 8.28 |
| CHEMBL1204235 | — | — | 1 | 8.10 |
| CHEMBL1204237 | — | — | 1 | 8.00 |
| CHEMBL1204229 | — | — | 1 | 7.89 |
| CHEMBL1204246 | — | — | 1 | 7.80 |
| CHEMBL1204254 | — | — | 1 | 7.75 |
| CHEMBL1204258 | — | — | 1 | 7.64 |
| CHEMBL1204257 | — | — | 1 | 7.58 |
| CHEMBL1204253 | — | — | 1 | 7.57 |
| CHEMBL1204232 | — | — | 1 | 7.55 |
| CHEMBL1204238 | — | — | 1 | 7.55 |
| CHEMBL1204244 | — | — | 1 | 7.54 |
| CHEMBL1204240 | — | — | 1 | 7.54 |
| CHEMBL1204230 | — | — | 1 | 7.52 |
| CHEMBL1204248 | — | — | 1 | 7.39 |
| CHEMBL1204239 | — | — | 1 | 7.29 |
| CHEMBL1204243 | — | — | 1 | 7.10 |
| CHEMBL1204241 | — | — | 1 | 7.02 |
| CHEMBL1204231 | — | — | 1 | 6.67 |
| CHEMBL1204255 | — | — | 1 | 6.60 |
| CHEMBL1204236 | — | — | 1 | 6.25 |
| CHEMBL1202594 | — | — | 1 | - |
| CHEMBL1204249 | — | — | 1 | - |
| CHEMBL1204233 | — | — | 1 | - |
| CHEMBL1204228 | — | — | 1 | - |
| CHEMBL1204242 | — | — | 1 | - |
| CHEMBL1204252 | — | — | 1 | - |
| CHEMBL1204251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204234 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1204250 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL1204245 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL1204235 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1204237 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1204229 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1204246 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1204254 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1204258 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1204257 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1204253 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1204232 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1204238 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1204244 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1204240 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL1204230 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1204248 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1204239 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL1204243 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL1204241 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1204231 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL1204255 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL1204236 | — | Ki | = | 561.0 | nM | 6.25 |
| CHEMBL1202594 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1204249 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204233 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204228 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1204242 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204252 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1204251 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204203 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1204247 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204256 | — | Ki | > | 1000.0 | nM | - |