Assay Detail
Binding
CHEMBL646605
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Binding affinity at human Adenosine A3 receptor expressed in HEK 293 cells by [125I]AB-MECA displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.00 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606312 | — | — | 1 | 8.11 |
| CHEMBL2113427 | — | — | 1 | 8.06 |
| CHEMBL2113428 | — | — | 1 | 7.76 |
| CHEMBL66393 | — | — | 1 | 7.56 |
| CHEMBL604636 | — | — | 1 | 7.51 |
| CHEMBL605468 | — | — | 1 | 7.39 |
| CHEMBL2113432 | — | — | 1 | 7.35 |
| CHEMBL2113441 | — | — | 1 | 7.33 |
| CHEMBL2113468 | — | — | 1 | 7.13 |
| CHEMBL263643 | — | — | 1 | 7.05 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.92 |
| CHEMBL2113420 | — | — | 1 | 6.89 |
| CHEMBL2113425 | — | — | 1 | 6.86 |
| CHEMBL2113426 | — | — | 1 | 6.80 |
| CHEMBL2113422 | — | — | 1 | 6.73 |
| CHEMBL2113467 | — | — | 1 | 6.71 |
| CHEMBL2113437 | — | — | 1 | 6.68 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.26 |
| CHEMBL2113429 | — | — | 1 | 6.19 |
| CHEMBL477444 | — | — | 1 | 5.89 |
| CHEMBL2113433 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606312 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2113427 | — | Ki | = | 8.78 | nM | 8.06 |
| CHEMBL2113428 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL66393 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL604636 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL605468 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL2113432 | — | Ki | = | 44.3 | nM | 7.35 |
| CHEMBL2113441 | — | Ki | = | 46.3 | nM | 7.33 |
| CHEMBL2113468 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL263643 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2113420 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL2113425 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL2113426 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL2113422 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL2113467 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL2113437 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL388757 | N6-BENZYLADENOSINE | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2113429 | — | Ki | = | 647.0 | nM | 6.19 |
| CHEMBL477444 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL2113433 | — | Ki | = | 1860.0 | nM | 5.73 |