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Compound Detail

CHEMBL2113425

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CC(C)SC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL2113425
Phase Preclinical
Structure Type MOL
InChI Key SZBYGIUFYSGXQI-SCFUHWHPSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

393.5
MW (Da)
1.94
ALogP
9
HBA
3
HBD
105.3
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H27N5O3S
MW 393.51
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness 0.19

Activity Summary

Ki 3 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.39 7.39 41.0 1
Adenosine receptor A3
CHEMBL256
Ki 6.86 6.86 137.0 1
Adenosine receptor A2a
CHEMBL302
Ki 4.99 4.99 10250.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10212125 10.1021/jm981090+ Adenosine receptor A1 1
10212125 10.1021/jm981090+ Adenosine receptor A2a 1
10212125 10.1021/jm981090+ Adenosine receptor A3 1
10212125 10.1021/jm981090+ Adenosine receptors; A1 & A3 1

Data from ChEMBL 36 via Core Engine