Assay Detail
Binding
CHEMBL641313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-CGS- 21980 from Adenosine A2A receptor of rat striatal membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.10 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.24 |
| CHEMBL477444 | — | — | 1 | 5.06 |
| CHEMBL2113425 | — | — | 1 | 4.99 |
| CHEMBL2113468 | — | — | 1 | 4.87 |
| CHEMBL2113467 | — | — | 1 | 4.73 |
| CHEMBL263643 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL477444 | — | Ki | = | 8750.0 | nM | 5.06 |
| CHEMBL2113425 | — | Ki | = | 10250.0 | nM | 4.99 |
| CHEMBL2113468 | — | Ki | = | 13540.0 | nM | 4.87 |
| CHEMBL2113467 | — | Ki | = | 18780.0 | nM | 4.73 |
| CHEMBL263643 | — | Ki | = | 19010.0 | nM | 4.72 |