Assay Detail
Binding
CHEMBL646660
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Equilibrium dissociation constant for [3H]DPCPX binding to Adenosine A1 receptor from DDT1 MF2 cell membranes
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | DDT1 MF2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New irreversible adenosine A(1) antagonists based on FSCPX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 9.38 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321218 | — | — | 2 | 9.51 |
| CHEMBL108552 | — | — | 2 | 9.51 |
| CHEMBL327708 | — | — | 2 | 9.48 |
| CHEMBL107646 | — | — | 2 | 9.39 |
| CHEMBL107499 | — | — | 2 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321218 | — | Kd | = | 0.31 | nM | 9.51 |
| CHEMBL108552 | — | Kd | = | 0.31 | nM | 9.51 |
| CHEMBL327708 | — | Kd | = | 0.33 | nM | 9.48 |
| CHEMBL321218 | — | Kd | = | 0.36 | nM | 9.44 |
| CHEMBL108552 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL107646 | — | Kd | = | 0.41 | nM | 9.39 |
| CHEMBL107499 | — | Kd | = | 0.46 | nM | 9.34 |
| CHEMBL107646 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL107499 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL327708 | — | Kd | = | 0.71 | nM | 9.15 |