Assay Detail
Functional
CHEMBL646667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTP-gamma-S, binding to human adenosine A1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.41 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.38 |
| CHEMBL27952 | — | — | 1 | 7.67 |
| CHEMBL284216 | — | — | 1 | 7.51 |
| CHEMBL66393 | — | — | 1 | 7.37 |
| CHEMBL27809 | — | — | 1 | 6.85 |
| CHEMBL417292 | — | — | 1 | 6.66 |
| CHEMBL71385 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | EC50 | = | 4.15 | nM | 8.38 |
| CHEMBL27952 | — | EC50 | = | 21.5 | nM | 7.67 |
| CHEMBL284216 | — | EC50 | = | 31.2 | nM | 7.51 |
| CHEMBL66393 | — | EC50 | = | 43.1 | nM | 7.37 |
| CHEMBL27809 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL417292 | — | EC50 | = | 218.0 | nM | 6.66 |
| CHEMBL71385 | — | EC50 | > | 10000.0 | nM | - |