Assay Detail
Binding
CHEMBL646709
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Affinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.24 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52648 | — | — | 1 | 7.63 |
| CHEMBL2112630 | — | — | 1 | 7.49 |
| CHEMBL122746 | — | — | 1 | 7.08 |
| CHEMBL2112627 | — | — | 1 | 6.96 |
| CHEMBL2112619 | — | — | 1 | 6.96 |
| CHEMBL2112626 | — | — | 1 | 6.89 |
| CHEMBL338399 | — | — | 1 | 6.72 |
| CHEMBL340299 | — | — | 1 | 6.70 |
| CHEMBL2112632 | — | — | 1 | 6.62 |
| CHEMBL2112625 | — | — | 1 | 6.43 |
| CHEMBL2112620 | — | — | 1 | 6.40 |
| CHEMBL2112631 | — | — | 1 | 6.09 |
| CHEMBL121997 | — | — | 1 | 6.07 |
| CHEMBL2112622 | — | — | 1 | 5.45 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 5.15 |
| CHEMBL122345 | — | — | 1 | 5.11 |
| CHEMBL2112633 | — | — | 1 | 5.07 |
| CHEMBL2112612 | — | — | 1 | 4.96 |
| CHEMBL2112623 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52648 | — | Ki | = | 23.6 | nM | 7.63 |
| CHEMBL2112630 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL122746 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL2112627 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2112619 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2112626 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL338399 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL340299 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2112632 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL2112625 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL2112620 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2112631 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL121997 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL2112622 | — | Ki | = | 3590.0 | nM | 5.45 |
| CHEMBL305686 | CORDYCEPIN | Ki | = | 7120.0 | nM | 5.15 |
| CHEMBL122345 | — | Ki | = | 7840.0 | nM | 5.11 |
| CHEMBL2112633 | — | Ki | = | 8470.0 | nM | 5.07 |
| CHEMBL2112612 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL2112623 | — | Ki | = | 16900.0 | nM | 4.77 |