Assay Detail
Binding
CHEMBL646764
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Inhibitory activity towards Alpha-mannosidase from Jack bean
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.46 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84104 | — | — | 1 | 5.13 |
| CHEMBL84941 | — | — | 1 | 4.58 |
| CHEMBL79727 | — | — | 1 | 4.28 |
| CHEMBL2206826 | — | — | 1 | 4.23 |
| CHEMBL83278 | — | — | 1 | 4.10 |
| CHEMBL421340 | — | — | 1 | - |
| CHEMBL309850 | — | — | 1 | - |
| CHEMBL2206827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84104 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL84941 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL79727 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL2206826 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL83278 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL421340 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL309850 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL2206827 | — | Ki | = | 120000.0 | nM | - |