Assay Detail
Functional
CHEMBL646843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity against Human Androgen receptor expressed in CV-1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent, orally active, nonsteroidal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.74 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302870 | — | — | 1 | 9.52 |
| CHEMBL390728 | — | — | 1 | 8.40 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302870 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL390728 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL27769 | STANOLONE | EC50 | = | 5.0 | nM | 8.30 |