Assay Detail
Binding
CHEMBL646866
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Binding affinity was tested on Alpha-1 adrenergic receptor using radioligand [3H](+)-pentazocine binding assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.22 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127006 | — | — | 1 | 9.40 |
| CHEMBL128442 | — | — | 1 | 9.10 |
| CHEMBL337709 | — | — | 1 | 8.43 |
| CHEMBL435397 | — | — | 1 | 8.41 |
| CHEMBL423349 | — | — | 1 | 8.41 |
| CHEMBL134717 | — | — | 1 | 8.41 |
| CHEMBL135530 | — | — | 1 | 8.41 |
| CHEMBL135528 | — | — | 1 | 8.33 |
| CHEMBL334440 | — | — | 1 | 8.33 |
| CHEMBL135930 | — | — | 1 | 8.17 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.00 |
| CHEMBL134607 | — | — | 1 | 7.74 |
| CHEMBL336378 | — | — | 1 | 7.52 |
| CHEMBL134504 | — | — | 1 | 7.40 |
| CHEMBL135738 | — | — | 1 | 7.20 |
| CHEMBL135687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127006 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL128442 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL337709 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL435397 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL423349 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL134717 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL135530 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL135528 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL334440 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL135930 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL134607 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL336378 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL134504 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL135738 | — | Ki | = | 63.2 | nM | 7.20 |
| CHEMBL135687 | — | Ki | > | 3960.0 | nM | - |