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Assay Detail

CHEMBL646945

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Binding
Inhibition of angiotensin I converting enzyme in silico
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Crippen GM.
J Med Chem (1997) 40 : 3161 -3172
PubMed 9379435 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.65 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL110925 1 9.10
CHEMBL322266 1 8.70
CHEMBL326902 1 8.50
CHEMBL105971 1 8.50
CHEMBL105890 1 8.40
CHEMBL577 ENALAPRILAT ANHYDROUS 4.0 1 8.40
CHEMBL41289 1 8.30
CHEMBL110870 1 8.30
CHEMBL108606 1 8.10
CHEMBL107700 1 8.00
CHEMBL80906 1 8.00
CHEMBL110439 1 8.00
CHEMBL10465 1 8.00
CHEMBL23849 1 7.90
CHEMBL108988 1 7.90
CHEMBL110444 1 7.70
CHEMBL62955 1 7.60
CHEMBL110375 1 7.50
CHEMBL107635 1 7.50
CHEMBL109178 1 7.40
CHEMBL111578 1 7.20
CHEMBL1560 CAPTOPRIL 4.0 1 7.10
CHEMBL325544 1 6.90
CHEMBL321012 1 6.90
CHEMBL106193 1 6.80
CHEMBL10247 THIORPHAN -1.0 1 6.50
CHEMBL322291 1 5.60
CHEMBL105790 1 5.50
CHEMBL38405 1 -
CHEMBL323051 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL110925 IC50 = 0.7943 nM 9.10
CHEMBL322266 IC50 = 1.995 nM 8.70
CHEMBL326902 IC50 = 3.162 nM 8.50
CHEMBL105971 IC50 = 3.162 nM 8.50
CHEMBL105890 IC50 = 3.981 nM 8.40
CHEMBL577 ENALAPRILAT ANHYDROUS IC50 = 3.981 nM 8.40
CHEMBL41289 IC50 = 5.012 nM 8.30
CHEMBL110870 IC50 = 5.012 nM 8.30
CHEMBL108606 IC50 = 7.943 nM 8.10
CHEMBL107700 IC50 = 10.0 nM 8.00
CHEMBL80906 IC50 = 10.0 nM 8.00
CHEMBL110439 IC50 = 10.0 nM 8.00
CHEMBL10465 IC50 = 10.0 nM 8.00
CHEMBL23849 IC50 = 12.59 nM 7.90
CHEMBL108988 IC50 = 12.59 nM 7.90
CHEMBL110444 IC50 = 19.95 nM 7.70
CHEMBL62955 IC50 = 25.12 nM 7.60
CHEMBL110375 IC50 = 31.62 nM 7.50
CHEMBL107635 IC50 = 31.62 nM 7.50
CHEMBL109178 IC50 = 39.81 nM 7.40
CHEMBL111578 IC50 = 63.1 nM 7.20
CHEMBL1560 CAPTOPRIL IC50 = 79.43 nM 7.10
CHEMBL325544 IC50 = 125.89 nM 6.90
CHEMBL321012 IC50 = 125.89 nM 6.90
CHEMBL106193 IC50 = 158.49 nM 6.80
CHEMBL10247 THIORPHAN IC50 = 316.23 nM 6.50
CHEMBL322291 IC50 = 2511.89 nM 5.60
CHEMBL105790 IC50 = 3162.28 nM 5.50
CHEMBL38405 IC50 = 1000000000.0 nM -
CHEMBL323051 IC50 = 1000000000.0 nM -