Assay Detail
Binding
CHEMBL646967
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Inhibitory concentration was evaluated by inhibiting 50% of Angiotensin I Converting Enzyme activity using 50 uM N-Cbz-Phe-His-Leu as substrate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.37 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171850 | — | — | 1 | 6.15 |
| CHEMBL175110 | — | — | 1 | 5.80 |
| CHEMBL173919 | — | — | 1 | 5.40 |
| CHEMBL54601 | — | — | 1 | 5.40 |
| CHEMBL172787 | — | — | 1 | 5.35 |
| CHEMBL174237 | — | — | 1 | 5.30 |
| CHEMBL173287 | — | — | 1 | 5.00 |
| CHEMBL2110258 | — | — | 1 | 5.00 |
| CHEMBL55286 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171850 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL175110 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL173919 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL54601 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL172787 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL174237 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL173287 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2110258 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL55286 | — | IC50 | = | 12000.0 | nM | 4.92 |