Assay Detail
Binding
CHEMBL646974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new class of angiotensin II receptor antagonists with a novel acidic bioisostere
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.50 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292430 | — | — | 1 | 7.38 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 6.96 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.82 |
| CHEMBL291689 | — | — | 1 | 6.58 |
| CHEMBL291502 | — | — | 1 | 6.51 |
| CHEMBL57783 | — | — | 1 | 6.44 |
| CHEMBL299269 | — | — | 1 | 6.41 |
| CHEMBL58938 | — | — | 1 | 6.38 |
| CHEMBL57242 | AZILSARTAN | 3.0 | 1 | 6.38 |
| CHEMBL293308 | — | — | 1 | 6.32 |
| CHEMBL294140 | — | — | 1 | 6.21 |
| CHEMBL292914 | — | — | 1 | 6.10 |
| CHEMBL294598 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292430 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL191 | LOSARTAN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL291689 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL291502 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL57783 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL299269 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL58938 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL57242 | AZILSARTAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL293308 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL294140 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL292914 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL294598 | — | IC50 | = | 850.0 | nM | 6.07 |