Compound Detail
CHEMBL292914
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Basic Information
| ChEMBL ID | CHEMBL292914 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XITHKDUQJMGBFZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
470.5
MW (Da)
4.99
ALogP
8
HBA
2
HBD
123.5
PSA (Ų)
0.32
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor CHEMBL3374 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | IC50 | = | 790.0 | nM | 6.1 | Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angio... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00319-O | Rattus norvegicus | 2 |
| - | 10.1016/0960-894X(95)00319-O | Type-1 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine