Assay Detail
Binding
CHEMBL646983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of specific binding of [125I]angiotensin II (0.2 nM) to angiotensin II receptor in bovine adrenal cortex
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.41 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308884 | — | — | 1 | 7.18 |
| CHEMBL347300 | — | — | 1 | 7.16 |
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 6.96 |
| CHEMBL148667 | — | — | 1 | 6.89 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.82 |
| CHEMBL344546 | — | — | 1 | 6.60 |
| CHEMBL299597 | — | — | 1 | 6.50 |
| CHEMBL151675 | — | — | 1 | 6.47 |
| CHEMBL358916 | — | — | 1 | 6.44 |
| CHEMBL147248 | — | — | 1 | 6.44 |
| CHEMBL356654 | — | — | 1 | 6.41 |
| CHEMBL57242 | AZILSARTAN | 3.0 | 1 | 6.38 |
| CHEMBL341833 | — | — | 1 | 6.36 |
| CHEMBL149239 | — | — | 1 | 6.34 |
| CHEMBL150270 | — | — | 1 | 6.33 |
| CHEMBL146859 | — | — | 1 | 6.30 |
| CHEMBL347051 | — | — | 1 | 6.27 |
| CHEMBL48242 | — | — | 1 | 6.26 |
| CHEMBL294140 | — | — | 1 | 6.21 |
| CHEMBL148465 | — | — | 1 | 6.16 |
| CHEMBL146809 | — | — | 1 | 6.14 |
| CHEMBL150128 | — | — | 1 | 6.12 |
| CHEMBL345773 | — | — | 1 | 6.12 |
| CHEMBL149539 | — | — | 1 | 6.05 |
| CHEMBL151436 | — | — | 1 | 6.04 |
| CHEMBL146974 | — | — | 1 | 6.01 |
| CHEMBL150426 | — | — | 1 | 6.00 |
| CHEMBL357587 | — | — | 1 | - |
| CHEMBL147532 | — | — | 1 | - |
| CHEMBL149169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308884 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL347300 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1016 | CANDESARTAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL148667 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL191 | LOSARTAN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL344546 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL299597 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL151675 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL358916 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL147248 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL356654 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL57242 | AZILSARTAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL341833 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL149239 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL150270 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL146859 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL347051 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL48242 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL294140 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL148465 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL146809 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL150128 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL345773 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL149539 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL151436 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL146974 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL150426 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL357587 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL147532 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL149169 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359201 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL151632 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL358902 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL150049 | — | IC50 | > | 1000.0 | nM | - |