Assay Detail
Binding
CHEMBL646987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membrane preparations of guinea pig adrenal glands
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Adrenal gland |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.00 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7641 | — | — | 1 | 7.02 |
| CHEMBL274447 | — | — | 1 | 6.32 |
| CHEMBL7632 | — | — | 1 | 5.64 |
| CHEMBL171681 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7641 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL274447 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL7632 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL171681 | — | IC50 | = | 9400.0 | nM | 5.03 |