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Assay Detail

CHEMBL646997

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of rauwolscine from rat Alpha-2B adrenergic receptor expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Capnocytophaga
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Alpha-2B adrenergic receptor (CHEMBL266)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Munk SA, Harcourt DA, Arasasingham PN, Burke JA, Kharlamb AB, Manlapaz CA, Padillo EU, Roberts D, Runde E, Williams L, Wheeler LA, Garst ME.
J Med Chem (1997) 40 : 18 -23
PubMed 9016324 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.37 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49137 1 7.77
CHEMBL844 BRIMONIDINE 4.0 1 7.28
CHEMBL308570 1 7.09
CHEMBL75257 1 6.66
CHEMBL78190 1 6.42
CHEMBL432155 1 6.38
CHEMBL77913 1 6.36
CHEMBL1022 1 6.23
CHEMBL74544 1 6.19
CHEMBL75491 1 5.92
CHEMBL76457 1 5.82
CHEMBL308863 1 5.60
CHEMBL74449 1 5.03
CHEMBL1019 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49137 Ki = 17.0 nM 7.77
CHEMBL844 BRIMONIDINE Ki = 52.0 nM 7.28
CHEMBL308570 Ki = 82.0 nM 7.09
CHEMBL75257 Ki = 220.0 nM 6.66
CHEMBL78190 Ki = 380.0 nM 6.42
CHEMBL432155 Ki = 421.0 nM 6.38
CHEMBL77913 Ki = 434.0 nM 6.36
CHEMBL1022 Ki = 590.0 nM 6.23
CHEMBL74544 Ki = 640.0 nM 6.19
CHEMBL75491 Ki = 1200.0 nM 5.92
CHEMBL76457 Ki = 1500.0 nM 5.82
CHEMBL308863 Ki = 2500.0 nM 5.60
CHEMBL74449 Ki = 9300.0 nM 5.03
CHEMBL1019 Ki > 10000.0 nM -