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Compound Detail

CHEMBL1022

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Clc1cccc(Cl)c1Nc1ncc[nH]1

Basic Information

ChEMBL ID CHEMBL1022
Phase Preclinical
Structure Type MOL
InChI Key JMIQFISPBOHMQG-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

228.1
MW (Da)
3.46
ALogP
2
HBA
2
HBD
40.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H7Cl2N3
MW 228.08
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness -1.16

Activity Summary

Ki 4 meas. best 7.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 7.02 7.02 95.0 1
Alpha-2B adrenergic receptor
CHEMBL266
Ki 6.23 6.23 590.0 1
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 5.96 5.96 1100.0 1
Adrenergic receptor alpha-1
CHEMBL2094251
Ki 5.22 5.22 6000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9016324 10.1021/jm9605142 Adrenergic receptor alpha-1 1
9016324 10.1021/jm9605142 Alpha-2A adrenergic receptor 1
9016324 10.1021/jm9605142 Alpha-2B adrenergic receptor 1
9016324 10.1021/jm9605142 Alpha-2C adrenergic receptor 1

Data from ChEMBL 36 via Core Engine