Assay Detail
Binding
CHEMBL645797
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Displacement of prazosin from Alpha-1 adrenergic receptors of human cerebral cortex homogenate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.21 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49137 | — | — | 1 | 5.85 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 5.75 |
| CHEMBL308570 | — | — | 1 | 5.68 |
| CHEMBL75257 | — | — | 1 | 5.38 |
| CHEMBL1022 | — | — | 1 | 5.22 |
| CHEMBL308863 | — | — | 1 | 5.18 |
| CHEMBL77913 | — | — | 1 | 5.08 |
| CHEMBL76457 | — | — | 1 | 4.96 |
| CHEMBL432155 | — | — | 1 | 4.80 |
| CHEMBL78190 | — | — | 1 | 4.80 |
| CHEMBL74544 | — | — | 1 | 4.62 |
| CHEMBL75491 | — | — | 1 | - |
| CHEMBL1019 | — | — | 1 | - |
| CHEMBL74449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49137 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL308570 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL75257 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL1022 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL308863 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL77913 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL76457 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL432155 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL78190 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL74544 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL75491 | — | Ki | > | 28000.0 | nM | - |
| CHEMBL1019 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL74449 | — | Ki | > | 100000.0 | nM | - |