Assay Detail
Binding
CHEMBL647019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against rat cortical alpha-1 adrenergic receptor labeled with [3H]prazosin radioligand
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.56 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127171 | — | — | 1 | 8.60 |
| CHEMBL338482 | — | — | 1 | 8.48 |
| CHEMBL2112644 | — | — | 1 | 8.47 |
| CHEMBL124638 | — | — | 1 | 8.36 |
| CHEMBL338520 | — | — | 1 | 8.34 |
| CHEMBL332589 | — | — | 1 | 8.32 |
| CHEMBL126424 | — | — | 1 | 8.25 |
| CHEMBL340705 | — | — | 1 | 8.13 |
| CHEMBL339810 | — | — | 1 | 8.04 |
| CHEMBL419240 | — | — | 1 | 8.02 |
| CHEMBL340873 | — | — | 1 | 7.92 |
| CHEMBL339490 | — | — | 1 | 7.88 |
| CHEMBL2112645 | — | — | 2 | 7.57 |
| CHEMBL126407 | — | — | 1 | 7.56 |
| CHEMBL340895 | — | — | 1 | 7.46 |
| CHEMBL125902 | — | — | 1 | 7.28 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 7.05 |
| CHEMBL124700 | — | — | 1 | 7.00 |
| CHEMBL124818 | — | — | 1 | 7.00 |
| CHEMBL340301 | — | — | 1 | 7.00 |
| CHEMBL338982 | — | — | 1 | 7.00 |
| CHEMBL330827 | — | — | 1 | 7.00 |
| CHEMBL435612 | — | — | 1 | 7.00 |
| CHEMBL124069 | — | — | 1 | 7.00 |
| CHEMBL126536 | — | — | 1 | 6.91 |
| CHEMBL126253 | — | — | 1 | 6.69 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.22 |
| CHEMBL126484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127171 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL338482 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2112644 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL124638 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL338520 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL332589 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL126424 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL340705 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL339810 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL419240 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL340873 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL339490 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL2112645 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL126407 | — | Ki | = | 27.7 | nM | 7.56 |
| CHEMBL340895 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL125902 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL124700 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL435612 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL124818 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL340301 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2112645 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL338982 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL330827 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL124069 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL126536 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL126253 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL41 | FLUOXETINE | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL126484 | — | Ki | = | - | nM | - |