Assay Detail
Binding
CHEMBL647024
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Binding affinity towards Alpha-1 adrenergic receptor in rat cerebral cortex membranes using [3H]prazosin as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.10 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33150 | — | — | 1 | 7.19 |
| CHEMBL33258 | — | — | 1 | 5.00 |
| CHEMBL445055 | — | — | 1 | - |
| CHEMBL430914 | — | — | 1 | - |
| CHEMBL285066 | — | — | 1 | - |
| CHEMBL34287 | — | — | 1 | - |
| CHEMBL2113340 | — | — | 1 | - |
| CHEMBL2113339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33150 | — | Ki | = | 64.9 | nM | 7.19 |
| CHEMBL33258 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL445055 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL430914 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL285066 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL34287 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2113340 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2113339 | — | Ki | > | 1000.0 | nM | - |