Assay Detail
Binding
CHEMBL647125
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Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentration
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Alkylating prazosin analogue: irreversible label for alpha 1-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.09 | 9.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.79 |
| CHEMBL268768 | — | — | 1 | 9.16 |
| CHEMBL6347 | — | — | 1 | 8.47 |
| CHEMBL6340 | — | — | 1 | 8.36 |
| CHEMBL266223 | — | — | 1 | 8.35 |
| CHEMBL6358 | — | — | 1 | 7.64 |
| CHEMBL6219 | — | — | 1 | 7.53 |
| CHEMBL6342 | — | — | 1 | 7.40 |
| CHEMBL6343 | — | — | 1 | 7.17 |
| CHEMBL6314 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | IC50 | = | 0.1622 | nM | 9.79 |
| CHEMBL268768 | — | IC50 | = | 0.6918 | nM | 9.16 |
| CHEMBL6347 | — | IC50 | = | 3.388 | nM | 8.47 |
| CHEMBL6340 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL266223 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL6358 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL6219 | — | IC50 | = | 29.51 | nM | 7.53 |
| CHEMBL6342 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL6343 | — | IC50 | = | 67.61 | nM | 7.17 |
| CHEMBL6314 | — | IC50 | = | 102.33 | nM | 6.99 |