Assay Detail
Binding
CHEMBL647162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for alpha-1 adrenoceptor of rat cerebral cortex was determined by ligand binding using [3H]prazosin.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.51 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 7.61 |
| CHEMBL355655 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279516 | INDORAMIN | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL355655 | — | Ki | = | 38.9 | nM | 7.41 |