Assay Detail
Binding
CHEMBL647189
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Binding affinity against human Alpha-2c adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.36 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323579 | — | — | 1 | 6.69 |
| CHEMBL95578 | — | — | 1 | 6.54 |
| CHEMBL180561 | — | — | 1 | 6.49 |
| CHEMBL99864 | — | — | 1 | 6.45 |
| CHEMBL316495 | — | — | 1 | 6.36 |
| CHEMBL95290 | — | — | 1 | 6.33 |
| CHEMBL100045 | — | — | 1 | 6.29 |
| CHEMBL320736 | — | — | 1 | 6.05 |
| CHEMBL5483012 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323579 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL95578 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL180561 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL99864 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL316495 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL95290 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL100045 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL320736 | — | Ki | = | 884.0 | nM | 6.05 |
| CHEMBL5483012 | — | Ki | = | 912.0 | nM | 6.04 |