Assay Detail
Binding
CHEMBL647199
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Affinity constant towards human recombinant Alpha-1B adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 8.00 |
| CHEMBL37212 | — | — | 1 | 7.69 |
| CHEMBL37883 | — | — | 1 | 7.20 |
| CHEMBL37962 | — | — | 1 | 6.59 |
| CHEMBL543741 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL37212 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL37883 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL37962 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL543741 | — | Ki | = | 707.95 | nM | 6.15 |