Assay Detail
Binding
CHEMBL647201
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Affinity to human Alpha-1B adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.25 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306792 | — | — | 1 | 7.82 |
| CHEMBL72768 | — | — | 1 | 7.39 |
| CHEMBL540542 | — | — | 1 | 7.18 |
| CHEMBL70751 | — | — | 1 | 7.16 |
| CHEMBL540035 | — | — | 1 | 7.12 |
| CHEMBL72441 | — | — | 1 | 6.91 |
| CHEMBL553276 | — | — | 1 | 6.77 |
| CHEMBL70692 | — | — | 1 | 6.62 |
| CHEMBL74114 | — | — | 1 | 6.42 |
| CHEMBL70326 | — | — | 1 | 6.29 |
| CHEMBL70563 | — | — | 1 | 6.19 |
| CHEMBL70691 | — | — | 1 | 6.16 |
| CHEMBL542402 | — | — | 1 | 6.10 |
| CHEMBL554416 | — | — | 1 | 6.08 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 6.08 |
| CHEMBL70973 | — | — | 1 | 6.04 |
| CHEMBL74071 | — | — | 1 | 6.00 |
| CHEMBL544290 | — | — | 1 | 5.89 |
| CHEMBL74467 | — | — | 1 | 5.88 |
| CHEMBL72724 | — | — | 1 | 5.69 |
| CHEMBL70740 | — | — | 1 | 5.67 |
| CHEMBL419448 | — | — | 1 | 5.64 |
| CHEMBL70634 | — | — | 1 | 5.53 |
| CHEMBL71479 | — | — | 1 | 5.46 |
| CHEMBL71001 | — | — | 1 | 5.34 |
| CHEMBL72958 | NS-49 | — | 1 | 4.95 |
| CHEMBL302698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306792 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL72768 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL540542 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL70751 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL540035 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL72441 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL553276 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL70692 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL74114 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL70326 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL70563 | — | Ki | = | 645.65 | nM | 6.19 |
| CHEMBL70691 | — | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL542402 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL554416 | — | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL70973 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL74071 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL544290 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL74467 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL72724 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL70740 | — | Ki | = | 2137.96 | nM | 5.67 |
| CHEMBL419448 | — | Ki | = | 2290.87 | nM | 5.64 |
| CHEMBL70634 | — | Ki | = | 2951.21 | nM | 5.53 |
| CHEMBL71479 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL71001 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL72958 | NS-49 | Ki | = | 11220.18 | nM | 4.95 |
| CHEMBL302698 | — | Ki | < | 10000.0 | nM | - |