Assay Detail
Binding
CHEMBL647206
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Compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.91 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294562 | — | — | 1 | 5.55 |
| CHEMBL60068 | — | — | 1 | 5.18 |
| CHEMBL26717 | — | — | 1 | 4.00 |
| CHEMBL43021 | — | — | 1 | - |
| CHEMBL112038 | — | — | 1 | - |
| CHEMBL112357 | — | — | 1 | - |
| CHEMBL112351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294562 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL60068 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL26717 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL43021 | — | Ki | = | 660000.0 | nM | - |
| CHEMBL112038 | — | Ki | = | 2900000.0 | nM | - |
| CHEMBL112357 | — | Ki | = | 3900000.0 | nM | - |
| CHEMBL112351 | — | Ki | = | 1400000.0 | nM | - |