Assay Detail
Binding
CHEMBL647207
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Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.22 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 7.68 |
| CHEMBL59994 | — | — | 1 | 6.17 |
| CHEMBL60434 | — | — | 1 | 6.12 |
| CHEMBL294562 | — | — | 1 | 5.55 |
| CHEMBL121531 | — | — | 1 | 5.42 |
| CHEMBL38681 | — | — | 1 | 5.35 |
| CHEMBL39928 | — | — | 1 | 5.19 |
| CHEMBL60068 | — | — | 1 | 5.18 |
| CHEMBL275595 | — | — | 1 | 5.15 |
| CHEMBL6409 | CGS-19281A | — | 1 | 4.92 |
| CHEMBL121570 | — | — | 1 | 4.66 |
| CHEMBL121252 | — | — | 1 | 4.39 |
| CHEMBL287360 | — | — | 1 | 4.33 |
| CHEMBL97282 | — | — | 1 | 4.12 |
| CHEMBL26717 | — | — | 1 | 4.00 |
| CHEMBL290890 | — | — | 1 | - |
| CHEMBL43021 | — | — | 1 | - |
| CHEMBL40081 | — | — | 1 | - |
| CHEMBL41647 | — | — | 1 | - |
| CHEMBL36909 | — | — | 1 | - |
| CHEMBL333578 | — | — | 1 | - |
| CHEMBL112964 | — | — | 1 | - |
| CHEMBL95873 | — | — | 1 | - |
| CHEMBL120975 | — | — | 1 | - |
| CHEMBL112357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL59994 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL60434 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL294562 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL121531 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL38681 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL39928 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL60068 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL275595 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL6409 | CGS-19281A | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL121570 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL121252 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL287360 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL97282 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL26717 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL290890 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL43021 | — | Ki | = | 660000.0 | nM | - |
| CHEMBL40081 | — | Ki | = | 460000.0 | nM | - |
| CHEMBL41647 | — | Ki | = | 1400000.0 | nM | - |
| CHEMBL36909 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL333578 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL112964 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL95873 | — | Ki | = | 680000.0 | nM | - |
| CHEMBL120975 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL112357 | — | Ki | = | 3900000.0 | nM | - |