Assay Detail
Binding
CHEMBL647211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Diazepam-Sensitive fraction of GABA-A benzodiazepine receptors
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.42 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6597 | Ro-154513 | — | 1 | 8.28 |
| CHEMBL415290 | Ro-151310 | — | 1 | 8.27 |
| CHEMBL6440 | — | — | 1 | 8.01 |
| CHEMBL7290 | — | — | 1 | 7.85 |
| CHEMBL6655 | — | — | 1 | 7.80 |
| CHEMBL6793 | — | — | 1 | 6.30 |
| CHEMBL6407 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6597 | Ro-154513 | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL415290 | Ro-151310 | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL6440 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL7290 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL6655 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL6793 | — | Ki | = | 499.3 | nM | 6.30 |
| CHEMBL6407 | — | Ki | = | 3489.0 | nM | 5.46 |