Assay Detail
Binding
CHEMBL647263
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Inhibitory concentration against Bcl-xl
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.36 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.30 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 5.66 |
| CHEMBL334615 | — | — | 1 | 5.58 |
| CHEMBL339835 | — | — | 1 | 5.13 |
| CHEMBL135650 | — | — | 1 | 4.14 |
| CHEMBL133255 | — | — | 1 | - |
| CHEMBL134871 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL334615 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL339835 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL135650 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL133255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL134871 | — | IC50 | > | 100000.0 | nM | - |