Assay Detail
Binding
CHEMBL647267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity was determined against baker's yeast Alpha-Glucosidase
15
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraols
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.92 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86772 | — | — | 3 | 7.99 |
| CHEMBL88413 | — | — | 2 | 6.40 |
| CHEMBL313375 | — | — | 1 | 5.63 |
| CHEMBL88408 | — | — | 1 | 5.53 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 4.04 |
| CHEMBL87120 | — | — | 3 | - |
| CHEMBL86865 | — | — | 3 | - |
| CHEMBL314403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86772 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL88413 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL313375 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL88408 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 91900.0 | nM | 4.04 |
| CHEMBL87120 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86865 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL87120 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86865 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL88413 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL86865 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86772 | — | IC50 | > | 999.0 | nM | - |
| CHEMBL87120 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL314403 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL86772 | — | IC50 | > | 300000.0 | nM | - |