Assay Detail
Binding
CHEMBL647272
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Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.29 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109783 | — | — | 1 | 6.50 |
| CHEMBL1076 | DESGLYMIDODRINE | -1.0 | 1 | 4.07 |
| CHEMBL136560 | (1R,2S)-PHENYLPROPANOLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109783 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1076 | DESGLYMIDODRINE | EC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL136560 | (1R,2S)-PHENYLPROPANOLAMINE | EC50 | = | 280000.0 | nM | - |