Assay Detail
Binding
CHEMBL647284
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Binding affinity was determined for the alpha-1B adrenergic receptor
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.74 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.26 |
| CHEMBL358406 | — | — | 1 | 6.81 |
| CHEMBL358253 | — | — | 1 | 6.67 |
| CHEMBL279436 | — | — | 1 | 6.48 |
| CHEMBL346649 | — | — | 1 | 6.41 |
| CHEMBL359375 | — | — | 1 | 6.28 |
| CHEMBL151825 | — | — | 1 | 6.28 |
| CHEMBL41844 | — | — | 1 | 6.16 |
| CHEMBL148552 | — | — | 1 | 6.14 |
| CHEMBL347559 | — | — | 1 | 5.99 |
| CHEMBL347499 | — | — | 1 | 5.93 |
| CHEMBL146815 | — | — | 1 | 5.93 |
| CHEMBL357061 | — | — | 1 | 5.80 |
| CHEMBL347501 | — | — | 1 | 5.80 |
| CHEMBL151045 | — | — | 1 | 5.72 |
| CHEMBL151878 | — | — | 1 | 5.57 |
| CHEMBL356829 | — | — | 1 | 5.56 |
| CHEMBL357681 | — | — | 1 | 5.51 |
| CHEMBL149263 | — | — | 1 | 5.47 |
| CHEMBL147077 | — | — | 3 | 5.44 |
| CHEMBL355910 | — | — | 1 | 5.41 |
| CHEMBL347522 | — | — | 1 | 5.28 |
| CHEMBL356623 | — | — | 1 | 5.26 |
| CHEMBL150696 | — | — | 1 | 4.61 |
| CHEMBL151668 | — | — | 1 | 4.54 |
| CHEMBL150743 | — | — | 1 | 4.40 |
| CHEMBL146983 | — | — | 1 | 4.40 |
| CHEMBL356923 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL358406 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL358253 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL279436 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL346649 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL359375 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL151825 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL41844 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL148552 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL347559 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL347499 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL146815 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL357061 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL347501 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL151045 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL151878 | — | Ki | = | 2720.0 | nM | 5.57 |
| CHEMBL356829 | — | Ki | = | 2740.0 | nM | 5.56 |
| CHEMBL357681 | — | Ki | = | 3070.0 | nM | 5.51 |
| CHEMBL149263 | — | Ki | = | 3410.0 | nM | 5.47 |
| CHEMBL147077 | — | Ki | = | 3660.0 | nM | 5.44 |
| CHEMBL355910 | — | Ki | = | 3920.0 | nM | 5.41 |
| CHEMBL147077 | — | Ki | = | 4920.0 | nM | 5.31 |
| CHEMBL147077 | — | Ki | = | 5170.0 | nM | 5.29 |
| CHEMBL347522 | — | Ki | = | 5250.0 | nM | 5.28 |
| CHEMBL356623 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL150696 | — | Ki | = | 24400.0 | nM | 4.61 |
| CHEMBL151668 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL150743 | — | Ki | = | 39500.0 | nM | 4.40 |
| CHEMBL146983 | — | Ki | = | 39500.0 | nM | 4.40 |
| CHEMBL356923 | — | Ki | = | 45000.0 | nM | 4.35 |