Assay Detail
Binding
CHEMBL647297
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Binding affinity against Angiotensin I converting enzyme from rat testis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.97 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146746 | — | — | 1 | 6.59 |
| CHEMBL347763 | — | — | 1 | 6.18 |
| CHEMBL151631 | — | — | 1 | 5.96 |
| CHEMBL148777 | — | — | 1 | 5.92 |
| CHEMBL358903 | — | — | 1 | 5.92 |
| CHEMBL147285 | — | — | 1 | 5.75 |
| CHEMBL348205 | — | — | 1 | 5.75 |
| CHEMBL356858 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146746 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL347763 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL151631 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL148777 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL358903 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL147285 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL348205 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL356858 | — | Ki | = | 2200.0 | nM | 5.66 |