Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL647300

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Angiotensin I converting enzyme (ACE) purified from rat testis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Testis
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL2625)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Inguimbert N, Coric P, Poras H, Meudal H, Teffot F, Fournié-Zaluski MC, Roques BP.
J Med Chem (2002) 45 : 1477 -1486
PubMed 11906289 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 7.27 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35749 1 8.00
CHEMBL285447 1 8.00
CHEMBL38249 1 7.82
CHEMBL290492 1 7.75
CHEMBL35643 1 7.70
CHEMBL37276 1 7.58
CHEMBL38075 1 7.54
CHEMBL285204 1 7.48
CHEMBL37711 1 7.42
CHEMBL288584 1 7.40
CHEMBL2115345 1 7.39
CHEMBL285490 1 7.37
CHEMBL38235 1 7.33
CHEMBL285960 1 7.21
CHEMBL288911 1 7.19
CHEMBL290610 1 7.12
CHEMBL34876 1 7.11
CHEMBL289223 1 7.10
CHEMBL37841 1 6.89
CHEMBL287801 1 6.87
CHEMBL288302 1 6.82
CHEMBL287261 1 6.82
CHEMBL2114403 1 6.77
CHEMBL288814 1 6.54
CHEMBL289518 1 6.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35749 Ki = 10.0 nM 8.00
CHEMBL285447 Ki = 10.0 nM 8.00
CHEMBL38249 Ki = 15.0 nM 7.82
CHEMBL290492 Ki = 18.0 nM 7.75
CHEMBL35643 Ki = 20.0 nM 7.70
CHEMBL37276 Ki = 26.0 nM 7.58
CHEMBL38075 Ki = 29.0 nM 7.54
CHEMBL285204 Ki = 33.0 nM 7.48
CHEMBL37711 Ki = 38.0 nM 7.42
CHEMBL288584 Ki = 40.0 nM 7.40
CHEMBL2115345 Ki = 41.0 nM 7.39
CHEMBL285490 Ki = 43.0 nM 7.37
CHEMBL38235 Ki = 47.0 nM 7.33
CHEMBL285960 Ki = 62.0 nM 7.21
CHEMBL288911 Ki = 65.0 nM 7.19
CHEMBL290610 Ki = 76.0 nM 7.12
CHEMBL34876 Ki = 77.0 nM 7.11
CHEMBL289223 Ki = 79.0 nM 7.10
CHEMBL37841 Ki = 130.0 nM 6.89
CHEMBL287801 Ki = 134.0 nM 6.87
CHEMBL288302 Ki = 150.0 nM 6.82
CHEMBL287261 Ki = 150.0 nM 6.82
CHEMBL2114403 Ki = 170.0 nM 6.77
CHEMBL288814 Ki = 290.0 nM 6.54
CHEMBL289518 Ki = 330.0 nM 6.48