Assay Detail
Binding
CHEMBL647301
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inhibitory activity on angiotensin I converting enzyme (ACE) using cbz-Phe-His-Leu as substrate.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.04 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159925 | — | — | 1 | 7.41 |
| CHEMBL1159940 | — | — | 1 | 6.92 |
| CHEMBL1159919 | — | — | 1 | 6.36 |
| CHEMBL1159920 | — | — | 1 | 6.18 |
| CHEMBL1159939 | — | — | 1 | 5.85 |
| CHEMBL1159942 | — | — | 1 | 5.60 |
| CHEMBL1159952 | — | — | 1 | 5.11 |
| CHEMBL1159924 | — | — | 1 | 4.89 |
| CHEMBL1159950 | — | — | 1 | - |
| CHEMBL1159953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159925 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1159940 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL1159919 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1159920 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL1159939 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1159942 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL1159952 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL1159924 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL1159950 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL1159953 | — | Ki | > | 5000.0 | nM | - |