Assay Detail
Binding
CHEMBL647364
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Binding Affinity against human Beta-1 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.15 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308351 | — | — | 1 | 7.10 |
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 6.49 |
| CHEMBL307647 | — | — | 1 | 6.14 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 5.80 |
| CHEMBL73917 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308351 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL174984 | TRETOQUINOL | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL307647 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL434 | ISOPROTERENOL | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL73917 | — | Ki | = | 6165.95 | nM | 5.21 |