Assay Detail
Binding
CHEMBL647399
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Inhibitory activity against angiotensin I converting enzyme
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.20 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20341 | — | — | 1 | 9.59 |
| CHEMBL287896 | — | — | 1 | 9.52 |
| CHEMBL410980 | — | — | 1 | 9.46 |
| CHEMBL19951 | — | — | 1 | 9.40 |
| CHEMBL20182 | — | — | 1 | 9.24 |
| CHEMBL19647 | — | — | 1 | 9.07 |
| CHEMBL283741 | — | — | 1 | 8.96 |
| CHEMBL19816 | — | — | 1 | 8.82 |
| CHEMBL282469 | — | — | 1 | 8.80 |
| CHEMBL279966 | — | — | 1 | 8.80 |
| CHEMBL19573 | — | — | 1 | 8.80 |
| CHEMBL19936 | — | — | 1 | 8.77 |
| CHEMBL1794012 | — | — | 1 | 8.72 |
| CHEMBL19755 | — | — | 1 | 8.60 |
| CHEMBL19494 | — | — | 1 | 8.52 |
| CHEMBL20574 | — | — | 1 | 8.48 |
| CHEMBL19070 | — | — | 1 | 8.46 |
| CHEMBL20067 | — | — | 1 | 8.40 |
| CHEMBL21025 | — | — | 1 | 8.40 |
| CHEMBL277238 | — | — | 1 | 8.25 |
| CHEMBL1794004 | — | — | 1 | 8.20 |
| CHEMBL20419 | — | — | 1 | 8.15 |
| CHEMBL20123 | — | — | 1 | 8.15 |
| CHEMBL20053 | — | — | 1 | 8.10 |
| CHEMBL19165 | — | — | 1 | 8.00 |
| CHEMBL282664 | — | — | 1 | 7.92 |
| CHEMBL20966 | — | — | 1 | 7.85 |
| CHEMBL51625 | — | — | 1 | 7.60 |
| CHEMBL1794014 | — | — | 1 | 7.55 |
| CHEMBL19935 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20341 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL287896 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL410980 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL19951 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL20182 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL19647 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL283741 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL19816 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL282469 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL279966 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL19573 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL19936 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1794012 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL19755 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL19494 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL20574 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL19070 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL20067 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL21025 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL277238 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1794004 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL20123 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL20419 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL20053 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL19165 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL282664 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL20966 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL51625 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1794014 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL19935 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL277707 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1794011 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL280203 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL19846 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL19621 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL20322 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL418738 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL283315 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL19820 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL20193 | — | IC50 | = | 220.0 | nM | 6.66 |