Assay Detail
Binding
CHEMBL647480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH-58261 from human Adenosine A2A receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.45 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330286 | — | — | 1 | 7.10 |
| CHEMBL302765 | — | — | 1 | 6.85 |
| CHEMBL65271 | — | — | 1 | 5.98 |
| CHEMBL329791 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330286 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL302765 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL65271 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL329791 | — | Ki | = | 1390.0 | nM | 5.86 |