Assay Detail
Binding
CHEMBL647493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH-58261 from human Adenosine A2A receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.50 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141550 | — | — | 1 | 8.02 |
| CHEMBL165073 | — | — | 1 | 6.47 |
| CHEMBL341376 | — | — | 1 | 6.37 |
| CHEMBL167915 | — | — | 1 | 6.30 |
| CHEMBL165910 | — | — | 1 | 6.21 |
| CHEMBL354161 | — | — | 1 | 6.16 |
| CHEMBL355415 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141550 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL165073 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL341376 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL167915 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL165910 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL354161 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL355415 | — | Ki | = | 1115.0 | nM | 5.95 |