Assay Detail
Binding
CHEMBL647515
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In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
A new potent inhibitor for angiotensin converting enzyme: (R,S)-captopril-F3
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.48 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347388 | — | — | 1 | 9.54 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | 8.44 |
| CHEMBL348513 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347388 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL348513 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 2400.0 | nM | 5.62 |