Assay Detail
Functional
CHEMBL647532
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Agonist activity against alpha-1 adrenergic receptor from rat vas deferens
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.66 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51358 | — | — | 1 | 7.30 |
| CHEMBL51479 | — | — | 1 | 7.21 |
| CHEMBL300628 | — | — | 1 | 6.52 |
| CHEMBL300053 | — | — | 1 | 6.47 |
| CHEMBL49953 | — | — | 1 | 5.80 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | - |
| CHEMBL541208 | — | — | 1 | - |
| CHEMBL51131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51358 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL51479 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL300628 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL300053 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL49953 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL597 | PHENTOLAMINE | EC50 | > | 1000.0 | nM | - |
| CHEMBL541208 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL51131 | — | EC50 | > | 10000.0 | nM | - |