Assay Detail
Binding
CHEMBL647533
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Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aorta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.96 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1706 | NAPHAZOLINE HYDROCHLORIDE | 4.0 | 1 | 7.92 |
| CHEMBL541105 | — | — | 1 | 6.70 |
| CHEMBL537830 | — | — | 1 | 6.70 |
| CHEMBL537161 | MEDETOMIDINE HYDROCHLORIDE | -1.0 | 1 | 6.51 |
| CHEMBL554581 | — | — | 1 | - |
| CHEMBL553231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1706 | NAPHAZOLINE HYDROCHLORIDE | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL541105 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL537830 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL537161 | MEDETOMIDINE HYDROCHLORIDE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL554581 | — | EC50 | = | 0.0077 | nM | - |
| CHEMBL553231 | — | EC50 | = | 0.00054 | nM | - |