Assay Detail
Binding
CHEMBL647556
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Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]-clonidine binding (0.4 nM) to rat isolated brain membranes by 50% was reported; 5.9*10e-8
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.23 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13852 | CIRAZOLINE | IC50 | = | 59.0 | nM | 7.23 |