Assay Detail
Binding
CHEMBL647559
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranes
28
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.63 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44558 | — | — | 1 | 8.15 |
| CHEMBL42909 | — | — | 1 | 7.72 |
| CHEMBL42242 | — | — | 1 | 7.54 |
| CHEMBL42309 | — | — | 1 | 7.41 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 7.39 |
| CHEMBL42237 | — | — | 1 | 7.29 |
| CHEMBL295359 | — | — | 1 | 7.28 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.20 |
| CHEMBL41980 | — | — | 1 | 7.15 |
| CHEMBL41420 | — | — | 1 | 7.07 |
| CHEMBL44501 | — | — | 4 | 7.07 |
| CHEMBL43071 | — | — | 1 | 6.96 |
| CHEMBL40542 | — | — | 1 | 6.82 |
| CHEMBL42291 | — | — | 1 | 6.70 |
| CHEMBL44528 | — | — | 1 | 6.57 |
| CHEMBL43762 | — | — | 4 | 6.52 |
| CHEMBL42047 | — | — | 1 | 6.51 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 6.29 |
| CHEMBL44257 | — | — | 1 | 6.00 |
| CHEMBL288765 | — | — | 1 | 5.89 |
| CHEMBL288531 | — | — | 1 | 5.68 |
| CHEMBL43930 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44558 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42909 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL42242 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL42309 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL42237 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL295359 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL41980 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL41420 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL44501 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL43071 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL44501 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL40542 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL42291 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL44528 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL43762 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL42047 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL43762 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL44257 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL43762 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL288765 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL44501 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL288531 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL43762 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL44501 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL43930 | — | IC50 | = | 8900.0 | nM | 5.05 |